Oxygen activation by P450cin: Protein and substrate mutagenesis

The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution

Ilme Schlichting, Joel Berendzen, Kelvin Chu et al. · Science · 2000 · 1.3K citations

Life Sciences, Biochemistry, Chemistry +14

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

Muneaki Imai, H. Shimada, Yoshihito Watanabe et al. · Proceedings of the National Academy of Sciences · 1989 · 374 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

Alfin D. N. Vaz, Dermot F. McGinnity, Minor J. Coon · Proceedings of the National Academy of Sciences · 1998 · 292 citations

Medicine, Biochemistry, Toxicology +17

A conserved residue of cytochrome P-450 is involved in heme-oxygen stability and activation

Susan A. Martinis, William M. Atkins, Patrick S. Stayton et al. · Journal of the American Chemical Society · 1989 · 276 citations

Life Sciences, Biochemistry, Chemistry +12

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

A D Vaz, Steven J. Pernecky, Gregory M. Raner et al. · Proceedings of the National Academy of Sciences · 1996 · 196 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16