H. Shimada

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

Muneaki Imai, H. Shimada, Yoshihito Watanabe et al. · Proceedings of the National Academy of Sciences · 1989 · 374 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Tadashi Ogishima, Hirotaka Shibata, H. Shimada et al. · Journal of Biological Chemistry · 1991 · 142 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role.

Fumiko Mitani, Hiromichi Suzuki, Junichi Hata et al. · Endocrinology · 1994 · 140 citations

Life Sciences, Endocrinology, Neurobiology +17

Role of THR-252 in Cytochrome P450CAM: A Study with Unnatural Amino Acid Mutagenesis

Yoko Kimata, H. Shimada, Tadaaki Hirose et al. · Biochemical and Biophysical Research Communications · 1995 · 129 citations

Medicine, Biochemistry, Pharmacology +7

Dynamic protein structures. Effects of pH on conformer stabilities at the ligand-binding site of bovine heart myoglobin carbonyl.

H. Shimada, Winslow S. Caughey · Journal of Biological Chemistry · 1982 · 111 citations · Full text

Life Sciences, Biochemistry, Biophysics +17