Concepedia

Discovery and optimization of nonpeptide HIV-1 protease inhibitors

Peter J. Tummino, J. V. N. Vara Prasad, Donna Ferguson, Carolyn Nouhan, Neil M.H. Graham, John M. Domagala, Edmund L. Ellsworth, Christopher Gajda, Susan E. Hagen, Elizabeth A. Lunney,

Bioorganic & Medicinal Chemistry · 1996 · 29 citations · 26 references

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References

26

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

, , +9

Active human immunodeficiency virus protease is required for viral infectivity.

Nancy E. Kohl, Emilio A. Emini, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text

, , +17

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

Jon H. Condra, William A. Schleif, O M Blahy et al. · Nature · 1995 · 979 citations

, , +16

Rational Design of Peptide-Based HIV Proteinase Inhibitors

Noel A. Roberts, Joseph A. Martin, Derek Kinchington et al. · Science · 1990 · 925 citations

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 836 citations

, , +16