Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

Huifang Huang, Rajiv Chopra, Gregory L. Verdine, +1

Science

Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

Marco Vignuzzi, Jeffrey K. Stone, Jamie J. Arnold, +2

Nature

BiologyViral EvolutionViral PopulationNatural SciencesEvolutionary Biology +8

Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA:  Evidence for an Induced Fit Mechanism^,

M.R. Sawaya, Rajendra Prasad, Samuel H. Wilson, +2

Biochemistry

Dna AnalysisMolecular BiologyNucleic Acid ChemistryProtein FoldingOpen Conformation +15

Structure of the Replicating Complex of a Pol α Family DNA Polymerase

Matthew C. Franklin, J Wang, Thomas A. Steitz

Cell

Nucleic Acid ChemistryViral Polymerase StructureBiochemistryReplicating ComplexViral Polymerase Mechanism +8

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

Rebecca Spence, Warren M. Kati, Karen S. Anderson, +1

Science

Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis

Dong Wang, David Bushnell, Kenneth D. Westover, +2

Cell

Transcriptional RegulationSystems BiologyNatural SciencesSubstrate SpecificityMolecular Biology +8

The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase

Y. Whitney Yin, Thomas A. Steitz

Cell

BiochemistryHelicase ActivityNatural SciencesRna Structure PredictionRna Biology +5

Multiple RNA Polymerase Conformations and GreA: Control of the Fidelity of Transcription

Dorothy A. Erie, Omid Hajiseyedjavadi, Mark C. Young, +1

Science

Viral Polymerase StructureMolecular BiologyGene TranscriptionSingle NucleotidesTranscriptional Regulation +14

A mutant T7 RNA polymerase as a DNA polymerase.

Rui Sousa, Robert Padilla

The EMBO Journal

Nucleic Acid ChemistryViral Polymerase StructureNatural SciencesViral Polymerase MechanismNucleic Acid Biochemistry +7

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations

Sean Johnson, Jeffrey S. Taylor, L.S. Beese

Proceedings of the National Academy of Sciences