Development of a highly sensitive high-performance liquid chromatographic method for measuring an anticancer drug, UCN-01, in human plasma or urine

Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies

Vinod P. Shah, K.K. Midha, S Dighe et al. · European Journal of Drug Metabolism and Pharmacokinetics · 1991 · 617 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +14

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

Shiro Akinaga, Katsushige Gomi, Makoto Morimoto et al. · PubMed · 1991 · 190 citations

Medicine, Oncology, Pharmacology +10

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

ISAMI TAKAHASHI, Eiji Kobayashi, Kozo Asano et al. · The Journal of Antibiotics · 1987 · 188 citations · Full text

Life Sciences, Biochemistry, Microbiology +5

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

Tadakazu Akiyama, Toshiko Yoshida, Tadayuki Tsujita et al. · PubMed · 1997 · 154 citations

Medicine, Cell Biology, Oncology +17

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

Caroline Seynaeve, Maryalice Stetler‐Stevenson, S Sebers et al. · PubMed · 1993 · 133 citations

Medicine, Oncology, Pharmacology +17