Tadakazu Akiyama

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

Tadakazu Akiyama, Toshiko Yoshida, Tadayuki Tsujita et al. · PubMed · 1997 · 154 citations

Medicine, Cell Biology, Oncology +17

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation

Yukimasa Shiotsu, Hitoshi Kiyoi, Yuichi Ishikawa et al. · Blood · 2009 · 130 citations · Full text

Medicine, Oncology, Pharmacology +14

Interleukin 3‐specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi‐factor‐dependent myeloid cell lines.

Shigeo Koyasu, Arinobu Tojo, Atsushi Miyajima et al. · The EMBO Journal · 1987 · 129 citations · Full text

Life Sciences, Cell Biology, Immunology +9

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogation

Kazuyo Sugiyama, Makiko Shimizu, Tadakazu Akiyama et al. · International Journal of Cancer · 2000 · 89 citations

Life Sciences, Cancer Biology, Oncology +17

UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?

Shiro Akinaga, Kentaro Sugiyama, Tadakazu Akiyama · PubMed · 2000 · 78 citations

Medicine, Oncology, Pharmacology +16