Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

Shiro Akinaga, Katsushige Gomi, Makoto Morimoto, +2

PubMed

Tumor BiologyOncologyProtein Kinase CAntitumor ActivityMedicine +12

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

Shiro Akinaga, Kayo Nomura, Katsushige Gomi, +1

Cancer Chemotherapy and Pharmacology

Antitumor ActivityProtein Kinase CMitomycin CMedicineReceptor Tyrosine Kinase +9

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

Shiro Akinaga, Kayo Nomura, Katsushige Gomi, +1

Cancer Chemotherapy and Pharmacology

Protein Kinase CCell-cycle DistributionOncogenic AgentMedicineTumor Suppressor +8

Novel 5-Aminoflavone Derivatives as Specific Antitumor Agents in Breast Cancer

Tsutomu Akama, Yasushi Shida, Toru Sugaya, +3

Journal of Medicinal Chemistry

Medicinal Chemistry5-Aminoflavone DerivativesBreast OncologyMedicineEstrogen Receptor +7

Design and Synthesis of Potent Antitumor 5,4‘-Diaminoflavone Derivatives Based on Metabolic Considerations

Tsutomu Akama, Hiroyuki Ishida, Yasushi Shida, +7

Journal of Medicinal Chemistry

‘ -Diaminoflavone DerivativesEstrogen ReceptorPharmaceutical ChemistryMedicinal ChemistryAnti-cancer Agent +14

Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole analogues of duocarmycin B2

Satoru Nagamura, Eiji Kobayashi, Katsushige Gomi, +1

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAntitumor ActivityBiochemistryMedicineNatural Sciences +9

Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics

Katsushige Gomi, Eiji Kobayashi, Katsunori Miyoshi, +7

Japanese Journal of Cancer Research

Synthesis and Antitumor Activity of Duocarmycin Derivatives: Modification of Segment A of Duocarmycin B2.

Satoru Nagamura, Akira Asai, Yutaka Kanda, +3

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryDuocarmycin DerivativesAntimicrobial ChemotherapySegment APharmaceutical Chemistry +18

Structure−Activity Relationships of the 7-Substituents of 5,4‘-Diamino-6,8,3‘-trifluoroflavone, a Potent Antitumor Agent

Tsutomu Akama, Hiroyuki Ishida, Uichiro Kimura, +2

Journal of Medicinal Chemistry

New Water-Soluble Duocarmycin Derivatives: Synthesis and Antitumor Activity of A-Ring Pyrrole Compounds Bearing β-Heteroarylacryloyl Groups

Nobuyoshi Amishiro, Satoru Nagamura, Eiji Kobayashi, +2

Journal of Medicinal Chemistry

Bioorganic ChemistryAntitumor ActivityChemoprevention StrategyOrganic ChemistryPharmacotherapy +18