Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

Hiroyoshi Hidaka, Masaki Inagaki, Sachiyo Kawamoto et al. · Biochemistry · 1984 · 2.7K citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications · 1986 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +10

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

Donald J. Giard, Stuart A. Aaronson, George J. Todaro et al. · JNCI Journal of the National Cancer Institute · 1973 · 2.3K citations

Veterinary Medicine, Oncology, Pathology +12

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

Hiroshi Kase, Kazuyuki Iwahashi, Satoshi Nakanishi et al. · Biochemical and Biophysical Research Communications · 1987 · 942 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

Maria Tomasz, Roselyn Lipman, Dondapati Chowdary et al. · Science · 1987 · 455 citations

Pharmacy, Cancer Biology, Molecular Biology +15