Intracellular scFvs against the viral E6 oncoprotein provoke apoptosis in human papillomavirus-positive cancer cells

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

Jan M.M. Walboomers, Marcel V. Jacobs, M. Michele Manos et al. · The Journal of Pathology · 1999 · 9K citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Human Papillomavirus Vaccines, Medicine, Pathology +10

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

E. Coli, Specific Activity, Molecular Biology +18

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Tohru Kiyono, Scott A. Foster, Jenn I. Koop et al. · Nature · 1998 · 1.2K citations

Developmental Biology, Cell Regulation, Rb/p16ink4a Inactivation +8

Against which human papillomavirus types shall we vaccinate and screen? the international perspective

Núbia Muñóz, F. Xavier Bosch, Xavier Castellsagué et al. · International Journal of Cancer · 2004 · 1.1K citations · Full text