Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents

Inhibition of topoisomerase I function by nitidine and fagaronine

Li‐Kai Wang, Randall K. Johnson, Sidney M. Hecht · Chemical Research in Toxicology · 1993 · 130 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

Smitha Antony, Keli Agama, Ze‐Hong Miao et al. · Cancer Research · 2007 · 127 citations · Full text

Medicine, Oncology, Pharmacology +14

Synthesis and evaluation of new 6-amino- substituted benzo[c]phenanthridine derivatives

Yves L. Janin, Alain Croisy, Jean‐François Riou et al. · Journal of Medicinal Chemistry · 1993 · 108 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

DNA cleavage assay for the identification of topoisomerase I inhibitors

Thomas S. Dexheimer, Yves Pommier · Nature Protocols · 2008 · 106 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Tsai‐Kun Li, Peter J. Houghton, Shyamal D. Desai et al. · PubMed · 2003 · 95 citations

Medicine, Oncology, Pharmacology +13