Tsai‐Kun Li

Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

David W. Crabb, Howard J. Edenberg, William Bosron et al. · Journal of Clinical Investigation · 1989 · 591 citations · Full text

Genetics, Genetic Epidemiology, Human Polymorphism +21

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

Chyuan-Chuan Wu, Tsai‐Kun Li, Lynn Farh et al. · Science · 2011 · 503 citations

Crystal Structure, Drug Target, Anticancer Drug Etoposide +20

Mechanism of Action of Camptothecin

Leroy F. Liu, Shyamal D. Desai, Tsai‐Kun Li et al. · Annals of the New York Academy of Sciences · 2000 · 469 citations

Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.

Shyamal D. Desai, Tsai‐Kun Li, Alexandra Rodriguez-Bauman et al. · PubMed · 2001 · 221 citations

Breast Oncology, Cell Death, Resistance Mechanism +19

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Tsai‐Kun Li, A. Y. Chen, C. Yu et al. · Genes & Development · 1999 · 214 citations · Full text

Dna Damage, Apoptosis, Molecular Biology +19