Highly facile approach to the formal total synthesis of camptothecin

The Palladium‐Catalyzed Cross‐Coupling Reactions of Organotin Reagents with Organic Electrophiles [New Synthetic Methods (58)]

J. K. Stille · Angewandte Chemie International Edition in English · 1986 · 3.4K citations

Natural Sciences, Chemistry, Catalysis +9

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Palladium(0)-Catalyzed Cross-Coupling Reaction of Alkoxydiboron with Haloarenes: A Direct Procedure for Arylboronic Esters

Tatsuo Ishiyama, Miki Murata, Norio Miyaura · The Journal of Organic Chemistry · 1995 · 1.6K citations

Natural Sciences, Chemistry, Catalysis +14

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicine, Oncology, Pharmacology +13