Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

I. Vermes, C. Haanen, H M Steffens-Nakken et al. · Journal of Immunological Methods · 1995 · 5.4K citations · Full text

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p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

Martina Müller, Sylvia Wilder, David Israeli et al. · The Journal of Experimental Medicine · 1998 · 893 citations · Full text

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Niels de Wind, Marleen Dekker, Anton Berns et al. · Cell · 1995 · 792 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

Shailaja Kasibhatla, Thomas Brunner, Laurent Genestier et al. · Molecular Cell · 1998 · 727 citations · Full text

Life Sciences, Immunology, Molecular Biology +16