Concepedia

Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

Sonia Moretti, Elisa Menicali, Pasquale Voce, Silvia Morelli, Sara Cantarelli, Marialuisa Sponziello, Renato Colella, Francesca Fallarino, Ciriana Orabona, Alessia Alunno,

The Journal of Clinical Endocrinology & Metabolism · 2014 · 81 citations · 30 references

DOIFull text

Open access

Abstract

For the first time, this study demonstrates a pivotal role of IDO1 in the suppression of lymphocyte function in thyroid carcinoma microenvironment.

References

30

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8K citations

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

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