Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations

Life Sciences, Cell Biology, Molecular Biology +17

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 2K citations

Medicine, Cancer Biology, Oncology +16

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese et al. · Nature · 2006 · 1.8K citations

Medicine, Molecular Biology, Oncology +16

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

Todd Waldman, K. W. Kinzler, Bert Vogelstein · PubMed · 1995 · 1.2K citations

Life Sciences, Cell Biology, Oncology +17

The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Jacob Falck, Niels Mailand, Randi G. Syljuåsen et al. · Nature · 2001 · 1.1K citations

Life Sciences, Cancer Biology, Molecular Biology +12