(−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Medicine, Biochemistry, Endocrinology +14

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

Medicine, Neurology, Neuroscience +17

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Theresa R. Bomfim, Letícia Forny‐Germano, Luciana B. Sathler et al. · Journal of Clinical Investigation · 2012 · 824 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

Kavon Rezai‐Zadeh, Doug Shytle, Nan Sun et al. · Journal of Neuroscience · 2005 · 707 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

Kavon Rezai‐Zadeh, Gary W. Arendash, Huayan Hou et al. · Brain Research · 2008 · 458 citations

Life Sciences, Neurobiology, Neuroscience +16