Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi, +13

Journal of Clinical Investigation

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

Theresa R. Bomfim, Letícia Forny‐Germano, Luciana B. Sathler, +14

Journal of Clinical Investigation

Synaptic TransmissionSynaptic SignalingInsulin SignalingSocial SciencesNeuroinflammation +26

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

Steven E. Arnold, Irwin Lucki, Bethany R. Brookshire, +8

Neurobiology of Disease

ObesityMetabolic SyndromeNutritionEnergy HomeostasisBody Composition +11

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

Mark Yarchoan, Jon B. Toledo, Edward B. Lee, +8

Acta Neuropathologica

Abnormal Serine PhosphorylationNeurodegenerative DiseasesAlzheimer's DiseaseSignal TransductionBiochemistry +7

Olfactory epithelium amyloid‐β and paired helical filament‐tau pathology in Alzheimer disease

Steven E. Arnold, Edward B. Lee, Paul J. Moberg, +5

Annals of Neurology

Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin

Konrad Talbot, Dan-Sung Cho, Wei‐Yi Ong, +7

Human Molecular Genetics

NeurotransmitterMicrotubular ProteinMolecular BiologyCytoskeletonNeurotransmission +16

Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia

Gregory C. Carlson, Konrad Talbot, Tobias Halene, +7

Proceedings of the National Academy of Sciences

Pv CellSynaptic TransmissionPsychopharmacologyClinical NeuroscienceNeurotransmission +21

Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function

Darrick T. Balu, Gregory C. Carlson, Konrad Talbot, +5

Hippocampus

Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location

Konrad Talbot, Natalia Louneva, Julia W. Cohen, +3

PLoS ONE

Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice—Potential Link to Cognitive Impairment in Schizophrenia

Yong Chen, Sookhee Bang, Mary F. McMullen, +7

Molecular Neurobiology

Dysbindin-null Mice—potential LinkPsychiatrySchizophreniaNeurochemical BiomarkersNeuroscience +4