Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

Angelo Benedetti, Mario Comporti, Hermann Esterbauer · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1980 · 1.1K citations

Pharmacy, Biochemistry, Toxicology +13

4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease

Irfan Rahman, Annemarie A. M. van Schadewijk, Ann J. L. Crowther et al. · American Journal of Respiratory and Critical Care Medicine · 2002 · 456 citations

Life Sciences, Biochemistry, Apoptosis +16

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

Ina Hubatsch, Marianne Ridderström, Bengt Mannervik · Biochemical Journal · 1998 · 375 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas

Shinichi Fukumoto, Naoko Yamauchi, Hisashi Moriguchi et al. · Clinical Cancer Research · 2005 · 294 citations · Full text

Medicine, Molecular Biology, Oncology +17

α,β-Unsaturated Aldehydes in Cigarette Smoke Release Inflammatory Mediators from Human Macrophages

Fabrizio Facchinetti, Francesco Amadei, Pierangelo Geppetti et al. · American Journal of Respiratory Cell and Molecular Biology · 2007 · 181 citations

Life Sciences, Immunology, Toxicology +17