Concepedia

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Patrick Poulin, Rhys D.O. Jones, Hannah M. Jones, Christopher R. Gibson, Malcolm Rowland, Jenny Y. Chien, Barbara J. Ring, Kimberly K. Adkison, M. Sherry Ku, Handan He,

Journal of Pharmaceutical Sciences · 2011 · 171 citations · 35 references

DOI

Concepts

References

35

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2002 · 560 citations

, , +14

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Ping Zhao, L Zhang, Joseph A. Grillo et al. · Clinical Pharmacology & Therapeutics · 2010 · 518 citations

, , +13

Mechanistic Approaches to Volume of Distribution Predictions: Understanding the Processes

Trudy Rodgers, Malcolm Rowland · Pharmaceutical Research · 2007 · 419 citations

, , +11

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

Hannah M. Jones, Neil Parrott, Karin Jorga et al. · Clinical Pharmacokinetics · 2006 · 348 citations

, , +14