Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

F W Alt, Rodney E. Kellems, Joseph R. Bertino et al. · Journal of Biological Chemistry · 1978 · 980 citations · Full text

Life Sciences, Genetics, Molecular Genetics +4

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

June L. Biedler, Barbara A. Spengler · Science · 1976 · 404 citations

Life Sciences, Cell Biology, Genetics +15

Five years' experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women

Roy Hertz, John Lewis, M. B. Lipsett · American Journal of Obstetrics and Gynecology · 1961 · 302 citations

Medicine, Gynecology, Oncology +10

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

M. D. Carman, Jan H. Schornagel, R S Rivest et al. · Journal of Clinical Oncology · 1984 · 145 citations

Medicine, Genetics, Molecular Genetics +13

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

Francis M. Sirotnak, Joseph I. DeGraw, D. M. Moccio et al. · Cancer Chemotherapy and Pharmacology · 1984 · 143 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12