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Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

Combinatorial ChemistryMedicinal ChemistryDrug TargetBiochemistryNatural SciencesStructure-based DiscoveryMedicineRational Drug DesignPharmacologyPharmaceutical Chemistry3,5-Bis Substituted AnilinopyrimidinesDrug DiscoveryTyrosine Kinase Ephb4