Structural basis for altered activity of M‐ and H‐isozyme forms of human lactate dehydrogenase

Jon Read, V.J. Winter, C.M. Eszes, +2

Proteins Structure Function and Bioinformatics

Aldehyde DehydrogenaseBiochemistryHuman Lactate DehydrogenaseNatural SciencesLactate Dehydrogenase +12

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Jessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, +21

Cell chemical biology

Cell BiologyPrc2 ComplexMolecular Biology

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Robin Willows, Matthew J. Sanders, Bing Xiao, +7

Biochemical Journal

Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia.

T M Narcisi, Carol C. Shoulders, S A Chester, +7

PubMed

Mechanism and <i>In Vitro</i> Pharmacology of TAK1 Inhibition by (5<i>Z</i>)-7-Oxozeaenol

Jiaquan Wu, Francoise Powell, Nicholas Larsen, +8

ACS Chemical Biology

Cancer BiologyTumor BiologyMolecular PharmacologyTak1 DeregulationSignaling Pathway +18

Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity

Angus Cameron, Jon Read, R. Tranter, +19

Journal of Biological Chemistry

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Jason G. Kettle, Husam Alwan, Michał Biśta, +16

Journal of Medicinal Chemistry

Tool CompoundsChemoprevention StrategySelective InhibitorsCancer BiologyOncology +16

Discovery of 5-Chloro-<i>N</i>²-[(1<i>S</i>)-1-(5-fluoropyrimidin-2-yl)ethyl]-<i>N</i>⁴-(5-methyl-1<i>H</i>-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Stephanos Ioannidis, Michelle L. Lamb, Tao Wang, +18

Journal of Medicinal Chemistry

Novel InhibitorPotent Jak2 InhibitorChemical BiologyPharmaceutical ChemistryMyeloid Neoplasia +22

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

Brian Sherer, Kenneth G. Hull, Oluyinka Green, +13

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityMedicinal ChemistryMedicineDrug DiscoveryAntibacterial Activity +8

Chloroquine Binds in the Cofactor Binding Site ofPlasmodium falciparum Lactate Dehydrogenase

Jon Read, Kay W. Wilkinson, R. Tranter, +2

Journal of Biological Chemistry