Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert, +8

Nature

Regenerative MedicineCell LineageCrypt-villus StructuresDevelopmental BiologyMedicine +7

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers, +8

Nature

Cell LineageCell SpecializationMarker Gene Lgr5Small IntestineGenetics +8

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Shankar Srinivas, Tomoko Watanabe, Chyuan‐Sheng Lin, +4

BMC Developmental Biology

Reporter Gene AssayNatural SciencesGeneticsMolecular BiologyTargeted Insertion +8

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

Hugo J.G. Snippert, Laurens G. van der Flier, Toshiro Sato, +8

Cell

Cell LineageNeutral CompetitionDevelopmental BiologyCell DivisionAdult Stem Cell +4

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio, +8

Nature

Cell RegulationCell SignalingNotch/γ-secretase InhibitionCell InteractionPathology +8

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Hua Tian, Brian Biehs, Søren Warming, +4

Nature

Developmental BiologyMedicineStem Cell MobilizationAdult Stem CellStem Cell Research +2

A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta, +7

Molecular Cell

Protein FunctionSignal TransductionSignaling PathwayReceptor Tyrosine KinaseCellular Biochemistry +4

Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium

Fatima El Marjou, Klaus‐Peter Janssen, Benny Hung‐Junn Chang, +7

genesis

Notch signals control the fate of immature progenitor cells in the intestine

Silvia Fré, Mathilde Huyghe, Philippos Mourikis, +3

Nature

Notch SignalsCell LineageDevelopmental BiologyCell DivisionCell Signaling +9

Requirement of <i>Math1</i> for Secretory Cell Lineage Commitment in the Mouse Intestine

Qi Yang, Nessan Bermingham, Milton J. Finegold, +1

Science