Concepedia

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Timothy P. Heffron, Megan Berry, Georgette M. Castanedo, Christine Chang, Irina Chuckowree, Jennafer Dotson, Adrian Folkes, Janet L. Gunzner, John Lesnick, Cristina Lewis,

Bioorganic & Medicinal Chemistry Letters · 2010 · 89 citations · 4 references

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4

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 746 citations · Full text

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Solubility and partitioning I: Solubility of nonelectrolytes in water

Samuel H. Yalkowsky, Shri C. Valvani · Journal of Pharmaceutical Sciences · 1980 · 575 citations

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Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Daniel P. Sutherlin, Deepak Sampath, Megan Berry et al. · Journal of Medicinal Chemistry · 2010 · 131 citations · Full text

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A Modified Bouveault Reaction for the Preparation of α,α-Dimethylamines from Amides

Stephen M. Denton · Synlett · 1999 · 37 citations

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