Jennafer Dotson

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1<i>H</i>-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-<i>d</i>][1,4]oxazepin-9-yl]-1<i>H</i>-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Chudi Ndubaku, Timothy P. Heffron, Steven T. Staben et al. · Journal of Medicinal Chemistry · 2013 · 176 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Xingrong Liu, Charles Baker‐Glenn et al. · Journal of Medicinal Chemistry · 2012 · 164 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Bryan Chan, Charles Baker‐Glenn et al. · Journal of Medicinal Chemistry · 2013 · 126 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Timothy P. Heffron, Megan Berry, Georgette M. Castanedo et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B

Ignacio Aliagas-Martin, Dan Burdick, Laura Corson et al. · Journal of Medicinal Chemistry · 2009 · 81 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14