Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

M.D. Burke, S. Thompson, Clifford R. Elcombe et al. · Biochemical Pharmacology · 1985 · 1.3K citations

Medicine, Pharmacology, Drug Metabolism +8

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

Heidi R. Kast-Woelbern, Bryan Goodwin, Paul T. Tarr et al. · Journal of Biological Chemistry · 2002 · 908 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators

Jean‐Marc Pascussi, Lionel Drocourt, Jean‐Michel Fabre et al. · Molecular Pharmacology · 2000 · 367 citations

Life Sciences, Molecular Biology, Pharmacology +11

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

Stephanie Faucette, Roy L. Hawke, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 2000 · 356 citations

Medicine, Biochemistry, Pharmacology +17

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450

Andrew J. Sonderfan, Michael P. Arlotto, David R. Dutton et al. · Archives of Biochemistry and Biophysics · 1987 · 327 citations

Life Sciences, Biochemistry, Endocrinology +14