Concepedia

Synthesis and structure–activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities

Myoung Ju Moon, Sang Kook Lee, Jong‐Won Lee, Woo Keun Song, Si Wouk Kim, Jae Il Kim, Chunghee Cho, Soo Jeong Choi, Yong‐Chul Kim

Bioorganic & Medicinal Chemistry · 2005 · 133 citations · 16 references

DOI

Concepts

References

16

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Ralph Hoessel, Sophie Leclerc, Jane Endicott et al. · Nature Cell Biology · 1999 · 814 citations

, , +13

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Sagrario Ortega, Ignacio Priéto, Junko Odajima et al. · Nature Genetics · 2003 · 793 citations

, , +14

Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Sophie Leclerc, Matthieu Garnier, Ralph Hoessel et al. · Journal of Biological Chemistry · 2001 · 723 citations · Full text

, , +13

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

Walter Filgueira de Azevedo, Sophie Leclerc, Laurent Meijer et al. · European Journal of Biochemistry · 1997 · 720 citations · Full text

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