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Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras

Hematological MalignancyActivated H-rasMast Cell DisorderMalignant Blood DisorderNormal Bone MarrowImmunologyHematologyAutoimmunityMedicineCell BiologyMyelopoiesisActive MutantMyeloid Neoplasia