Concepedia

Ras Inactivation

RAS Inactivation is a biochemical regulatory mechanism belonging to the class of molecular signaling events, specifically characterized by the transition of RAS family GTPases from their active GTP-bound state to an inactive GDP-bound state, thereby attenuating downstream oncogenic signaling pathways in cellular proliferation and survival.

487

Publications

36.5K

Citations

2.8K

Authors

805

Institutions

Publications per year

2017–2026

66

Parents

Publications

487

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

Reinhard Dammann, Chun Li, Jung‐Hoon Yoon et al. · Nature Genetics · 2000 · 1.1K citations

, , +15

A ras-related gene with transformation suppressor activity

Hitoshi Kitayama, Yoshikazu Sugimoto, Tomoko Matsuzaki et al. · Cell · 1989 · 961 citations

, , +12

Essential role for oncogenic Ras in tumour maintenance

Lynda Chin, Alice Tam, Jason H. Pomerantz et al. · Nature · 1999 · 872 citations

, , +16

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

Tanya Basu, David H. Gutmann, Jonathan A. Fletcher et al. · Nature · 1992 · 669 citations · Full text

, , +17

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

Irving S. Sigal, Martin Poe, Edward M. Scolnick · Proceedings of the National Academy of Sciences · 1984 · 616 citations · Full text

, , +14

1–5 of 487

Authors

2.8K

  1. RD
    Reinhard Dammann

    Justus-Liebig-Universität Gießen, Germany

    9 publications · 1.8K citations

    9

    h-index

  2. YK
    Yoel Kloog

    Tel Aviv University, Israel

    9 publications · 614 citations

    9

    h-index

  3. FM
    Frank McCormick

    University of California, San Francisco, United States

    9 publications · 919 citations

    9

    h-index

  4. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    8 publications · 400 citations

    8

    h-index

  5. SG
    Stephen G. Young

    University of California, Los Angeles, United States

    7 publications · 807 citations

    7

    h-index

1–5 of 2.8K

Institutions

805

  1. National Cancer Institute

    Bethesda, United States

    20 h-index

    66 publications

    6.9K citations

  2. Harvard University

    Cambridge, United States

    17 h-index

    61 publications

    7.4K citations

  3. University of California, San Francisco

    San Francisco, United States

    14 h-index

    48 publications

    6.2K citations

  4. Center for Cancer Research

    Bethesda, United States

    12 h-index

    43 publications

    5.8K citations

  5. Duke Medical Center

    Durham, United States

    11 h-index

    22 publications

    1.6K citations

  6. Johns Hopkins University

    Baltimore, United States

    11 h-index

    29 publications

    5.4K citations

  7. University of Michigan

    Ann Arbor, United States

    11 h-index

    43 publications

    4.1K citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    11 h-index

    41 publications

    10.3K citations

1–8 of 805

Venues

  1. Molecular and Cellular Biology

    MCB · 30 publications · 2.8K citations

    27

    h-index

  2. PubMed

    Repository · 39 publications · 2K citations

    24

    h-index

  3. Oncogene

    28 publications · 1.5K citations

    22

    h-index

  4. Journal of Biological Chemistry

    JBC · 23 publications · 1.9K citations

    21

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 2.8K citations

    17

    h-index

1–5