Concepedia

Ras-driven Tumorigenesis

RAS-Driven Tumorigenesis is a pathogenic process in which constitutive activation of RAS family oncoproteins initiates and sustains uncontrolled cellular proliferation, survival, and malignant transformation through dysregulation of downstream signaling pathways.

1.1K

Publications

101.3K

Citations

6.9K

Authors

1.4K

Institutions

Publications per year

2017–2026

166

Parents

Publications

1.1K

Analysis of lung tumor initiation and progression using conditional expression of oncogenic <i>K-ras</i>

Erica L. Jackson, Nicholas A. Willis, Kim L. Mercer et al. · Genes & Development · 2001 · 2K citations · Full text

, , +17

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu et al. · Nature · 2013 · 1.7K citations

, , +13

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Jessie Yanxiang Guo, Hsin-Yi Chen, Robin Mathew et al. · Genes & Development · 2011 · 1.3K citations · Full text

, , +17

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Leisa Johnson, Kim L. Mercer, Doron C. Greenbaum et al. · Nature · 2001 · 1.2K citations

, , +14

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

Marcus Kretzschmar, Jacqueline Doody, Inna Timokhina et al. · Genes & Development · 1999 · 1K citations · Full text

, , +17

1–5 of 1.1K

Authors

6.9K

  1. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    18 publications · 2.5K citations

    18

    h-index

  2. MB
    Mariano Barbacid

    Spanish National Cancer Research Centre, Spain

    12 publications · 3.2K citations

    12

    h-index

  3. AD
    Adrienne D. Cox

    University of North Carolina at Chapel Hill, United States

    12 publications · 1.2K citations

    12

    h-index

  4. JD
    Julian Downward

    The Honourable Society of Lincoln's Inn, United Kingdom

    11 publications · 1.6K citations

    11

    h-index

  5. ÀP
    Àngel Pellicer

    New York University, United States

    10 publications · 814 citations

    10

    h-index

1–5 of 6.9K

Institutions

1.4K

  1. Harvard University

    Cambridge, United States

    38 h-index

    187 publications

    32.9K citations

  2. National Cancer Institute

    Bethesda, United States

    35 h-index

    171 publications

    18.2K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    30 h-index

    197 publications

    16.4K citations

  4. University of California, San Francisco

    San Francisco, United States

    28 h-index

    145 publications

    25.7K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    27 h-index

    86 publications

    34.9K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    27 h-index

    153 publications

    42.4K citations

  7. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    24 h-index

    101 publications

    12.1K citations

  8. New York University

    New York, United States

    22 h-index

    87 publications

    16K citations

1–8 of 1.4K

Venues

  1. Oncogene

    84 publications · 6.8K citations

    51

    h-index

  2. PubMed

    Repository · 111 publications · 7.3K citations

    48

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 47 publications · 6.5K citations

    36

    h-index

  4. Molecular and Cellular Biology

    MCB · 44 publications · 4.1K citations

    34

    h-index

  5. Cancer Research

    41 publications · 3.5K citations

    33

    h-index

1–5