Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1)

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

David W. Hein, Mark A. Doll, Timothy D. Rustan et al. · Carcinogenesis · 1993 · 356 citations

Medicine, Pharmacology, Toxicology +16

Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.

Ingolf Cascorbi, Nikolaos Drakoulis, Jürgen Brockmöller et al. · PubMed · 1995 · 335 citations

Life Sciences, Genetics, Molecular Genetics +8

Human acetyltransferase polymorphisms

Denis M. Grant, Nicola Hughes, Susan A. Janezic et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 1997 · 266 citations

Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.

Denis M. Grant, Martin Blum, Marc A. Beer et al. · Molecular Pharmacology · 1991 · 250 citations

Life Sciences, Biochemistry, Genetics +11

Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.

Douglas A. Bell, Alaa F. Badawi, Nicholas P. Lang et al. · PubMed · 1995 · 232 citations

Medicine, Genetics, Molecular Genetics +17