Cellular Transformation by Human Papillomavirus DNA in Vitro

Susan Watts, William C. Phelps, Ronald S. Ostrow, Karen R. Zachow, Anthony J. Faras

Science · 1984 · 70 citations · 20 references

Abstract

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.

References

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