Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.

TLDR

The potential involvement of HPV types 6 and 11 in malignant genital tumors remains unclear. The study examined genital tumors and recurrent laryngeal papillomas for HPV 6 and 11 DNA. HPV 6 and 11 DNA were found in most genital and laryngeal papillomas, with HPV 11 present in all five atypical cervical condylomata and half of laryngeal papillomas, HPV 6 predominating in condylomata acuminata, and HPV 11 detected in 4 of 24 malignant tumors, supporting a genital origin of laryngeal papillomavirus infections.

Abstract

Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no HPV DNA was demonstrated. HPV 11 DNA was also found in all five atypical condylomata of the cervix included in this study. Condylomata acuminata mainly contained HPV 6 DNA. From 63 biopsy specimens, 41 clearly harbored HPV 6 DNA and 13 harbored HPV 11 DNA. In three tumors accurate typing was impossible, and in six additional ones neither HPV 6 nor HPV 11 DNA could be demonstrated. The data support a genital origin of laryngeal papillomavirus infections. In 4 of 24 malignant tumors, HPV 11 DNA or related sequences were demonstrated; 2 of the 4 were biopsy specimens from invasive cancer, and the other 2 originated from carcinomata in situ. A possible role of this or related papillomavirus types in the induction of malignant genital tumors remains to be elucidated.