Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 790 citations · Full text

Renal Pathology, Renal Cystogenesis, Renal Inflammation +19

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

Isaline Rowe, Marco Chiaravalli, Valeria Mannella et al. · Nature Medicine · 2013 · 478 citations · Full text

Metabolic Syndrome, Renal Function, Renal Disease +14

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

Tamio Yamaguchi, Jill C. Pelling, Nadja T. Ramaswamy et al. · Kidney International · 2000 · 348 citations · Full text

Cell Physiology, Urology, Signal Transduction +10

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

Vinita Takiar, Saori Nishio, Patricia Seo-Mayer et al. · Proceedings of the National Academy of Sciences · 2011 · 332 citations

Renal Inflammation, Cellular Physiology, Renal Function +16

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

Tamio Yamaguchi, Shizuko Nagao, Darren P. Wallace et al. · Kidney International · 2003 · 330 citations · Full text

Urology, Signal Transduction, Molecular Physiology +10