Sorin V. Fedeles

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

Sorin V. Fedeles, Xin Tian, Anna‐Rachel Gallagher et al. · Nature Genetics · 2011 · 256 citations

Medicine, Genetics, Genetic Epidemiology +12

Isolated polycystic liver disease genes define effectors of polycystin-1 function

Whitney Besse, Ke Dong, Jungmin Choi et al. · Journal of Clinical Investigation · 2017 · 200 citations · Full text

Engineering, Genetics, Human Polymorphism +24

Altered trafficking and stability of polycystins underlie polycystic kidney disease

Yiqiang Cai, Sorin V. Fedeles, Ke Dong et al. · Journal of Clinical Investigation · 2014 · 156 citations · Full text

Differential effects of Sec61α-, Sec62- and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

Sven Lang, Julia Benedix, Sorin V. Fedeles et al. · Journal of Cell Science · 2012 · 154 citations · Full text

Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity

Sorin V. Fedeles, Jae‐Seon So, Amol Shrikhande et al. · Journal of Clinical Investigation · 2015 · 60 citations · Full text

Molecular Regulation, Pathology, Cystic Disease +18