Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

James McGrath, Stefan Somlo, Svetlana Makova, +2

Cell

BiologyDevelopmental BiologyCell DivisionGeneticsMorphogenesis +2

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

Ming Ma, Xin Tian, Peter Igarashi, +2

Nature Genetics

Cilia SuppressesGenetic ModelsGenetic DisorderGeneticsPathogenesis +3

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

Sekiya Shibazaki, Zhiheng Yu, Saori Nishio, +8

Human Molecular Genetics

PathologyCell ProliferationCellular PhysiologySignaling PathwayCell Regulation +17

Mutations in SEC63 cause autosomal dominant polycystic liver disease

Sonia Dávila, Laszlo Furu, Ali G. Gharavi, +18

Nature Genetics

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Véronique Chauvet, Xin Tian, Hervé Husson, +8

Journal of Clinical Investigation

Molecular RegulationImmunologyMolecular BiologyCytoskeletonMechanotransduction +18

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

Lin Geng, Dayne Okuhara, Zhiheng Yu, +4

Journal of Cell Science

Environmental SignalingCilial LocalizationMolecular BiologyPathologyCellular Physiology +14

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation

Sorin V. Fedeles, Xin Tian, Anna‐Rachel Gallagher, +7

Nature Genetics

MedicineGeneticsGenetic EpidemiologyHuman PolymorphismPathology +10

Mutations in PRKCSH Cause Isolated Autosomal Dominant Polycystic Liver Disease

Airong Li, Sonia Dávila, Laszlo Furu, +6

The American Journal of Human Genetics

Hepatic DisordersHepatologyMendelian DisorderGenetic DisorderLiver Physiology +5

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

Georgia I. Anyatonwu, Manuel Estrada, Xin Tian, +2

Proceedings of the National Academy of Sciences

Cardiac MuscleCellular PhysiologyMolecular PharmacologyDisease PathophysiologySpontaneous Ca +15

Altered trafficking and stability of polycystins underlie polycystic kidney disease

Yiqiang Cai, Sorin V. Fedeles, Ke Dong, +13

Journal of Clinical Investigation