Concepedia

HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling

Zachary Hartman, Hua Zhao, Yehenew M. Agazie

Oncogene · 2012 · 65 citations · 45 references

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References

45

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A Ullrich, Lisa M. Coussens, Joel S. Hayflick et al. · Nature · 1984 · 2.8K citations

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

Jayanta Debnath, Senthil K. Muthuswamy, Joan S. Brugge · Methods · 2003 · 2K citations

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An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

Xuewu Zhang, Jodi Gureasko, Kui Shen et al. · Cell · 2006 · 1.6K citations · Full text

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Klaus Scheffzek, Mohammad Reza Ahmadian, Wolfgang Kabsch et al. · Science · 1997 · 1.6K citations

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Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains

Hideo Ogiso, Ryuichiro Ishitani, Osamu Nureki et al. · Cell · 2002 · 1.2K citations · Full text

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