p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Human Papillomavirus Vaccines, Medicine, Pathology +10

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

Dna Damage, Chemoprevention Strategy, Apoptosis +17

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Genetic Analysis, Mobility Shift Analysis, Genetic Testing +15

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Tumor Biology, Cancer Pathology, Molecular Pathogenesis +9

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Oncogenic Agent, Medicine, Molecular Biology +9