Remodelling of the natural product fumagillol employing a reaction discovery approach

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.2K citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

Donald E. Ingber, Takeshi Fujita, SHOJI KISHIMOTO et al. · Nature · 1990 · 1.3K citations

Inhibit Angiogenesis, Angiogenesis, Antifungal Agent +9

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Warren R. J. D. Galloway, Albert Isidro‐Llobet, David R. Spring · Nature Communications · 2010 · 854 citations · Full text

Combinatorial Chemistry, Diversity Oriented Synthesis, Molecular Diversity +11

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

Shenping Liu, Joanne Widom, Christopher W. Kemp et al. · Science · 1998 · 437 citations

Drug Target, Protein Assembly, Biomolecular Structure Prediction +17

Synthesis of tetrahydropyrans and related heterocycles via prins cyclization; extension to aza-prins cyclization

Clarisse Olier, Mustapha Kaafarani, Stéphane Gastaldi et al. · Tetrahedron · 2009 · 353 citations

Engineering, Heterocyclic, Prins Cyclization +9