Science · 2012 · 1.3K citations · 29 references
EngineeringMaterials EngineeringMaterials ScienceBiocompatibilityElectronic MaterialsSemiconductor DevicesDevice DesignImplant DesignImplant MaterialsImplant TechnologyImplantable Biomedical DevicesMedical Device DesignBiomedical ImplantsImplant DegradationImplantable Bioelectronic DevicesManufacturing Of ImplantsPorous SiliconSiliconSilicon Device MaterialsTransient Materials
A remarkable feature of modern silicon electronics is its ability to remain physically invariant, almost indefinitely for practical purposes. Although this characteristic is a hallmark of applications of integrated circuits that exist today, there might be opportunities for systems that offer the opposite behavior, such as implantable devices that function for medically useful time frames but then completely disappear via resorption by the body. We report a set of materials, manufacturing schemes, device components, and theoretical design tools for a silicon-based complementary metal oxide semiconductor (CMOS) technology that has this type of transient behavior, together with integrated sensors, actuators, power supply systems, and wireless control strategies. An implantable transient device that acts as a programmable nonantibiotic bacteriocide provides a system-level example.
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Dae‐Hyeong Kim, Nanshu Lu, Rui Ma et al. · Science · 2011 · 4.6K citations · Full text
Biodegradable luminescent porous silicon nanoparticles for in vivo applications
Ji‐Ho Park, Luo Gu, Geoffrey von Maltzahn et al. · Nature Materials · 2009 · 1.9K citations · Full text
Natural Sciences, Biomedical Engineering, Materials Science +14