Biocompatibility is a core concept and research area within materials science, bioengineering, and medicine, focused on evaluating the suitability of a material for use in contact with living tissue or biological systems. It investigates the nature and extent of the response of the biological system to the material, and conversely, the impact of the biological environment on the material properties, emphasizing the material's ability to perform its intended function without eliciting an unacceptable adverse local or systemic response.