Methylation ofO6-methylguanine-DNA methyltransferase gene is associated significantly withK-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma

Abstract

MGMT-promoter methylation in patients with gastric carcinoma was associated significantly with point mutations of K-ras at codons 12 and 13, lymph node invasion, tumor stage, and disease free survival. These associations indicate a significant role of MGMT methylation during gastric carcinogenesis.