Concepedia

Gene Inactivation

Gene Inactivation is a genetic phenomenon in which a functional gene loses its biological activity due to mutations, epigenetic modifications, or structural alterations, resulting in the cessation of its expression or the production of a nonfunctional gene product.

679

Publications

58.4K

Citations

4.1K

Authors

1.2K

Institutions

Publications per year

2017–2026

126

Parents

Publications

679

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Georg Dietzl, Doris Chen, Frank Schnorrer et al. · Nature · 2007 · 2.8K citations

, , +14

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G. Doench, Ella Hartenian, Daniel B. Graham et al. · Nature Biotechnology · 2014 · 1.7K citations · Full text

, , +17

Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse

Shigemi Hayashi, Andrew P. McMahon · Developmental Biology · 2002 · 1.4K citations

, , +17

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Manuel Stemmer, Thomas Thumberger, Maria del Sol Keyer et al. · PLoS ONE · 2015 · 1.2K citations · Full text

, , +15

New Vector for Efficient Allelic Replacement in Naturally Nontransformable, Low-GC-Content, Gram-Positive Bacteria

Maryvonne Arnaud, Arnaud Chastanet, Michel Débarbouillé · Applied and Environmental Microbiology · 2004 · 950 citations · Full text

, , +17

1–5 of 679

Authors

4.1K

  1. AB
    Andreas Bechthold

    University of Freiburg, Germany

    11 publications · 518 citations

    11

    h-index

  2. JJ
    Jianhua Ju

    Chinese Academy of Sciences, China

    10 publications · 451 citations

    10

    h-index

  3. SB
    Stephen B. Baylin

    Johns Hopkins University, United States

    6 publications · 1.5K citations

    6

    h-index

  4. LH
    Lutz Heide

    University of Tübingen, Germany

    5 publications · 360 citations

    5

    h-index

  5. RM
    Rolf Müller

    Saarland University, Germany

    5 publications · 260 citations

    5

    h-index

1–5 of 4.1K

Institutions

1.2K

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    123 publications

    11.5K citations

  2. Harvard University

    Cambridge, United States

    20 h-index

    77 publications

    12.3K citations

  3. Inserm

    Paris, France

    16 h-index

    64 publications

    3.9K citations

  4. Chinese Academy of Sciences

    Beijing, China

    16 h-index

    115 publications

    5.1K citations

  5. National Institutes of Health

    Bethesda, United States

    13 h-index

    46 publications

    3.4K citations

  6. University of Freiburg

    Freiburg im Breisgau, Germany

    12 h-index

    47 publications

    2.3K citations

  7. University of Tübingen

    Tübingen, Germany

    12 h-index

    38 publications

    3K citations

  8. Massachusetts General Hospital

    Boston, United States

    11 h-index

    72 publications

    11.5K citations

1–8 of 1.2K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 5.9K citations

    36

    h-index

  2. PubMed

    Repository · 34 publications · 2.4K citations

    22

    h-index

  3. PLoS ONE

    21 publications · 2.2K citations

    19

    h-index

  4. Applied and Environmental Microbiology

    AEM · 19 publications · 1.9K citations

    17

    h-index

  5. Journal of Bacteriology

    JB · 17 publications · 1.2K citations

    17

    h-index

1–5