M Toyota

Accelerated age-related CpG island methylation in ulcerative colitis.

Jean‐Pierre J. Issa, Nita Ahuja, M Toyota et al. · PubMed · 2001 · 639 citations

Inflammation, Cpg Island Hypermethylation, Epigenetic Change +10

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

Manel Esteller, M Toyota, Montse Sánchez‐Céspedes et al. · PubMed · 2000 · 543 citations

Epigenetic Change, Genetics, Dna Methylation +16

Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.

M Toyota, Nita Ahuja, Hiromu Suzuki et al. · PubMed · 1999 · 532 citations

Tumor Biology, Aberrant Methylation, Gastrointestinal Oncology +14

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

Manel Esteller, Silvia Tórtola, M Toyota et al. · PubMed · 2000 · 470 citations

P53 Mutational Status, Epigenetic Change, Genetics +18

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

Manel Esteller, Rosa Ana Risques, M Toyota et al. · PubMed · 2001 · 323 citations

Histone Modifications, Epigenetic Change, Genetics +20