In vivo antitumor activity of camptothecin incorporated in liposomes formulated with an artificial lipid and human serum albumin

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

Beppino C. Giovanella, John S. Stehlin, Monroe E. Wall et al. · Science · 1989 · 647 citations

Medicine, Oncology, Pharmacology +15

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

Robert Hertzberg, Mary Jo Caranfa, Sidney M. Hecht · Biochemistry · 1989 · 552 citations

Medicine, Biochemistry, Pharmacology +10

Rational Design of the First Spherical Supramolecular Dendrimers Self-Organized in a Novel Thermotropic Cubic Liquid-Crystalline Phase and the Determination of Their Shape by X-ray Analysis

Venkatachalapathy S. K. Balagurusamy, Goran Ungar, Virgil Percec et al. · Journal of the American Chemical Society · 1997 · 529 citations

Natural Sciences, Chemistry, Materials Science +17