Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

George G. Glenner, Caine W. Wong · Biochemical and Biophysical Research Communications · 1984 · 5.3K citations

Initial Report, Alzheimer's Disease, Dementia +11

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Robin Sherrington, Yuh‐Jin Liang, Ekaterina Rogaeva et al. · Nature · 1995 · 4K citations

Neurodegenerative Diseases, Early-onset Familial Alzheimer, Alzheimer's Disease +7

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj et al. · Science · 1995 · 2.6K citations

Alzheimer's Disease, Genetic Disorder, Genetics +12

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Protein Secretion, Presenilin Endoproteolysis, Biochemistry +13

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

Noor Embi, Dennis B. Rylatt, Philip Cohen · PubMed · 1980 · 915 citations

Muscle Function, Cellular Physiology, Muscle Physiology +21