Concepedia

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia

Tiffany R. Bell‐Horwath, Anish K. Vadukoot, Fathima Shazna Thowfeik, Guorui Li, Mark Wunderlich, James C. Mulloy, Edward J. Merino

Bioorganic & Medicinal Chemistry Letters · 2013 · 15 citations · 17 references

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17

Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

Anne Monks, Dominic A. Scudiero, Philip Skehan et al. · JNCI Journal of the National Cancer Institute · 1991 · 3.3K citations

, , +11

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert B. Hamanaka, William W. Wheaton et al. · Proceedings of the National Academy of Sciences · 2010 · 1.7K citations

, , +17

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

Dunyaporn Trachootham, Yan Zhou, Hui Zhang et al. · Cancer Cell · 2006 · 1.1K citations · Full text

, , +8

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith, Qi Wang, Chen-Shan Chin et al. · Nature · 2012 · 745 citations

, , +13

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

Jun-Ping Wei, Mark Wunderlich, Catherine Fox et al. · Cancer Cell · 2008 · 318 citations · Full text

, , +11