RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang, +17

Nature

Hematological MalignancyHematologyMyeloid NeoplasiaAcute Myeloid LeukaemiaRadiation Oncology +5

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su, Lei Dong, Chenying Li, +29

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Hengyou Weng, Huilin Huang, Huizhe Wu, +26

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaImmunologyStem Cell Research +7

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang, Rui Su, Yue Sheng, +25

Cancer Cell

Hematological MalignancyBiochemistryNatural SciencesAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +6

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, +36

Cancer Cell

Immune EvasionMedicineStem Cell MobilizationImmunologyStem Cell Research +6

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

Thi‐Sau Migone, Jian‐Xin Lin, Anna Cereseto, +4

Science

InflammationSystems BiologySignal TransductionAutoimmune DiseaseIl-2-independent Growth +13

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

Jun-Ping Wei, Mark Wunderlich, Catherine Fox, +9

Cancer Cell

Hematological MalignancyLineage PlasticityMll-af9 LeukemiaMedicineGenetics +8

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Hengyou Weng, Feng Huang, Zhaojin Yu, +31

Cancer Cell

Hematological MalignancyGlutamine MetabolismMedicineAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +6

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

Shigeki Takemoto, James C. Mulloy, Anna Cereseto, +10

Proceedings of the National Academy of Sciences

T-regulatory CellJanus KinasesImmunologyT CellsJak/stat Proteins +15

<i>TET1</i> plays an essential oncogenic role in <i>MLL</i> -rearranged leukemia

Hao Huang, Xi Jiang, Zejuan Li, +26

Proceedings of the National Academy of Sciences

Essential Oncogenic RoleChromatinHematological MalignancySystems BiologyMixed-phenotype Acute Leukemia +13