Induction of tumour necrosis factor-? by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Kevin J. Tracey, Bruce Beutler, Stephen F. Lowry et al. · Science · 1986 · 2.6K citations

Lung Inflammation, Immunology, Cell Death +18

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

K. Ohlsson, P. Björk, Magnus Bergenfeldt et al. · Nature · 1990 · 855 citations

Inflammation, Cytokine, Immunology +6

The role of IFN-<i>gamma</i> in the pathology of experimental endotoxemia.

Frederick P. Heinzel · The Journal of Immunology · 1990 · 255 citations · Full text

Tumour necrosis factor in man: Clinical and biological observations

Peter J. Selby, Stuart Hobbs, C. Viner et al. · British Journal of Cancer · 1987 · 203 citations · Full text

Inflammation, Immunology, Histopathology +10

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids

Gordon W. Rewcastle, Graham J. Atwell, Li Zhuang et al. · Journal of Medicinal Chemistry · 1991 · 194 citations

Implanted Colon 38, Medicinal Chemistry, Bioorganic Chemistry +15