Lai‐Ming Ching

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

Zachary Roberts, Nadège Goutagny, Pin‐Yu Perera et al. · The Journal of Experimental Medicine · 2007 · 165 citations · Full text

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8+ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

Arminder S. Jassar, Eiji Suzuki, Veena Kapoor et al. · Cancer Research · 2005 · 149 citations

Induction of tumour necrosis factor-? by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

Martin Philpott, Bruce C. Baguley, Lai‐Ming Ching · Cancer Chemotherapy and Pharmacology · 1995 · 108 citations

Inflammation, Tumour Necrosis Factor-, Medicine +12

Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.

LL Thomsen, Lai‐Ming Ching, Li Zhuang et al. · PubMed · 1991 · 105 citations

Chemoprevention Strategy, Immunology, Pathology +25

Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid.

Lindy L. Thomsen, Lai‐Ming Ching, Bruce C. Baguley · PubMed · 1990 · 89 citations

Inflammation, Medicinal Chemistry, Anti-inflammatory +12